Santa Isabel Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $4,200 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
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Top Santa Isabel Vacation Deals
Price found within the past 48 hours. Click for updated prices.
Central Hotel Panama Casco Viejo
Casco Viejo
CA $2,500
per person
Dec 17 - Dec 23
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9/10 Wonderful! (1,007 reviews)
This is a great hotel, and the location was perfect. The rooms were nice, and the staff were very friendly. I would highly recommend it.
Reviewed on Oct 1, 2026
Casa Mallet by Wynwood House
Casco Viejo
CA $2,030
per person
Dec 4 - Dec 11
found 1 day ago
Roundtrip non-stop flight included
Toronto (YTO) to Panama City (PTY)
9.8/10 Exceptional! (30 reviews)
I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect.
The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us.
I would stay here again in a heart beat.
It’s a must stay!
Reviewed on Sep 16, 2026
Ready to book your vacation to Santa Isabel?
Santa Isabel Hotel Deals
Private Ocean-Front Cabin with private bathroom on San Blas Island
Diablo Island Narganá Guna Yala
CA $268
CA $294 total
Nov 2 - Nov 3
includes taxes & fees
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."
Reviewed on Mar 15, 2026
Cocoloco - Catamaran Lagoon 52F SAN BLAS
El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
CA $2,356
CA $2,647 total
Oct 22 - Oct 23
includes taxes & fees
Caribbean Haven Of Nature 'Preci Beach'
Nombre de Dios Colon
10/10 Exceptional! (32 reviews)
"This is a great place to slow down and enjoy the sea and on-site amenities, including a pool, hot tub, sand volleyball court, and kid-friendly play spaces. This is very much a home that the owners make available to guests. Cone, the on-site custodian, is available and helpful. It is somewhat remote ..."
Reviewed on Oct 2, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Santa Isabel vacation package cost?
You'll find cheap prices from CA $1,321 on Expedia for your Santa Isabel escape. However, factors like the season, length of stay and your choice of hotel will influence how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
May, August and September are great times to search for cheap Santa Isabel vacation packages. Choosing to travel in quieter periods means you can generally find better prices on hotels and flights.
How many days is enough for Santa Isabel?
Usually, a handful of days is enough to explore the top sights during your Santa Isabel vacation. But if you want to have more time to chill out or go on day trips, think about extending your itinerary.
How to find the best Santa Isabel package deals?
Use Expedia's filters to find some of the best Santa Isabel package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your adventure for midweek, or browse for Santa Isabel package deals in the off-peak season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's usually best to book your vacation package well in advance.
Is it cheaper to book a Santa Isabel vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your car rental, flight and hotel into one great-value price and you could save hundreds of dollars. You'll generally land a better deal than booking each component individually. And you'll still have the freedom to create a tailored Santa Isabel vacation by choosing your favourite type of stay, airline and car class.
When to book a vacation package to Santa Isabel?
If you're planning a spur-of-the-moment Santa Isabel adventure, check out our last-minute deals that can be booked up to a week before you go. Prefer not to wait until the last minute? You can land terrific deals on your flights and hotels by booking ahead.
How to plan a trip to Santa Isabel?
- Choose when to go: Check your diary and get your bags packed. Your preferred season and the type of activities available will also help you decide when to escape to Santa Isabel.
- Plan your budget wisely: Besides the price of your stay, you'll need to consider other expenses too. These include transportation, food and flights. Also, put aside a little extra for unexpected costs that may arise during your trip to Santa Isabel.
- Decide your trip length: Consider how much time you'd like to spend discovering Santa Isabel. Plan your days so you can get to all the activities and attractions you're interested in at a leisurely pace.
- Combine your accommodations and airfare: Once you've settled on your trip dates and duration, book the ideal Santa Isabel vacation package for you.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
