Santa Isabel Vacation Packages

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Top Santa Isabel Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was CA $2,015, price is now CA $1,279 per person
CA $1,279
per person
Sep 19 - Sep 26
found 1 day ago
Roundtrip non-stop flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very good! (1,813 reviews)
This hotel is very old, no amenities and very noisy. Noise from street, pool filter and they have put refrigerator between beds next to your head. We ask the staff to give us the quite room, but she gave us a very noisy one. The breakfast was trible at 8 am they were out of eggs and coffee. When they bring some coffee and eggs after while coffee taste trible.

Reviewed on Jul 1, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was CA $3,213, price is now CA $1,622 per person
CA $1,622
per person
Sep 19 - Sep 26
found 1 day ago
Roundtrip non-stop flight included
Montreal (YMQ) to Panama City (PTY)
9.2/10 Wonderful! (1,008 reviews)
Beautiful hotel with great history! The location in Casco Viejo was perfect for our visit to Panama City and we were easily able to walk or order a car/Uber from there for various trips. We had a family suite, which was a king and full size bed room that worked well for our family of 3. The rooftop pool is small, but lovely and the restaurant near the pool was great with friendly staff. The Central Hotel is a gorgeous place and the staff at the front desk, door and restaurants were all nice and helpful.

Reviewed on Jun 30, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was CA $2,452, price is now CA $1,433 per person
CA $1,433
per person
Sep 19 - Sep 26
found 1 day ago
Roundtrip non-stop flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very good! (1,570 reviews)
The whole staff was extremely helpful.

Reviewed on Jul 1, 2026

Villa Marina Hotel

Villa Marina Hotel

3.5 out of 5
Price was CA $2,076, price is now CA $1,500 per person
CA $1,500
per person
Aug 3 - Aug 10
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9/10 Wonderful! (162 reviews)
staff helpful and very friendly, rooms super clean.

Reviewed on Jun 27, 2026

Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
San Francisco
Price was CA $1,813, price is now CA $1,313 per person
CA $1,313
per person
Sep 19 - Sep 26
found 1 day ago
Roundtrip non-stop flight included
Montreal (YMQ) to Panama City (PTY)
8.6/10 Excellent! (1,692 reviews)
el hotel esta muy bien ubicado

Reviewed on Jun 28, 2026

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Santa Isabel Hotel Deals

Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
The price is CA $2,773 per night from Jul 2 to Jul 3
CA $2,773
CA $3,063 total
Jul 2 - Jul 3
includes taxes & fees
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on Mar 15, 2026

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Private Ocean-Front Cabin with private bathroom on San Blas Island
Private wood Cabins on San Blas island - private bathroom

Private wood Cabins on San Blas island - private bathroom

2 out of 5
Wailidup Island Narganá Guna Yala
Get rates
Private wood Cabins on San Blas island - private bathroom
See all 39 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from CA $1,279 on Expedia for your Santa Isabel escape. However, factors like the season, length of stay and your choice of hotel will influence how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
May, August and September are great times to search for cheap Santa Isabel vacation packages. Choosing to travel in quieter periods means you can generally find better prices on hotels and flights.
How many days is enough for Santa Isabel?
Usually, a handful of days is enough to explore the top sights during your Santa Isabel vacation. But if you want to have more time to chill out or go on day trips, think about extending your itinerary.
How to find the best Santa Isabel package deals?
Use Expedia's filters to find some of the best Santa Isabel package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your adventure for midweek, or browse for Santa Isabel package deals in the off-peak season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's usually best to book your vacation package well in advance.
Is it cheaper to book a Santa Isabel vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your car rental, flight and hotel into one great-value price and you could save hundreds of dollars. You'll generally land a better deal than booking each component individually. And you'll still have the freedom to create a tailored Santa Isabel vacation by choosing your favourite type of stay, airline and car class.
When to book a vacation package to Santa Isabel?
If you're planning a spur-of-the-moment Santa Isabel adventure, check out our last-minute deals that can be booked up to a week before you go. Prefer not to wait until the last minute? You can land terrific deals on your flights and hotels by booking ahead.
How to plan a trip to Santa Isabel?

  1. Choose when to go: Check your diary and get your bags packed. Your preferred season and the type of activities available will also help you decide when to escape to Santa Isabel.
  2. Plan your budget wisely: Besides the price of your stay, you'll need to consider other expenses too. These include transportation, food and flights. Also, put aside a little extra for unexpected costs that may arise during your trip to Santa Isabel.
  3. Decide your trip length: Consider how much time you'd like to spend discovering Santa Isabel. Plan your days so you can get to all the activities and attractions you're interested in at a leisurely pace.
  4. Combine your accommodations and airfare: Once you've settled on your trip dates and duration, book the ideal Santa Isabel vacation package for you.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.